Gene name:
Lamtor5 (Hbxip;Xip) ;
Protein name:
Ragulator complex protein LAMTOR5 ;
Alternative:
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently.
Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
Subcellular Location:
Cytoplasm
Lysosome
Protein Attributes:
50:
MEATLEQHLE | DTMKNPSIVG | VLCTDSQGLN | LGCRGTLSDE | HAGVISVLAQ |
91:
QAARLTSDPT | DIPVVCLESD | NGNIMIQKHD | GITVAVHKMA | S
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Pig
ELISA Kit for Mouse Ragulator complex protein LAMTOR5
ELISA Kit for Mouse Ragulator complex protein LAMTOR5
ELISA Kit for Mouse Ragulator complex protein LAMTOR5
ELISA Kit for Mouse Ragulator complex protein LAMTOR5
CLIA Kit for Mouse Ragulator complex protein LAMTOR5
CLIA Kit for Mouse Ragulator complex protein LAMTOR5
CLIA Kit for Mouse Ragulator complex protein LAMTOR5
CLIA Kit for Mouse Ragulator complex protein LAMTOR5
Polyclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Polyclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Polyclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Polyclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Monoclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Monoclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Monoclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Monoclonal Antibody for Mouse Ragulator complex protein LAMTOR5
Protein for Mouse Ragulator complex protein LAMTOR5
Protein for Mouse Ragulator complex protein LAMTOR5
Protein for Mouse Ragulator complex protein LAMTOR5
Protein for Mouse Ragulator complex protein LAMTOR5
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
DBA/2 .
tissue :
Embryo .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Mammary gland .